In thalassemia patients bone disease becomes an important cause of morbidity. Support Center Support Center. Am J Hematol. The major circulating metabolite of vitamin D is serum 25 OHD, which has a half-life of between 10 and 19 days. See All.
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Clinical, biochemical and radiological manifestations of severe vitamin D deficiency in adolescents versus children: response to therapy. The major circulating metabolite of vitamin D is serum 25 OHD, which has a half-life of between 10 and 19 days. Treatment Identifying the optimal strategy for replacing vitamin D in patients with thalassemia is critical because adequate circulating levels of vitamin D are essential for optimal skeletal health and reducing fracture risk. A blunting of PTH response to VDD and a combination of hypovitaminosis D and hypoparathyroidism has been described in many thalassemic patients. Radiological changes include absent or irregular line of ossification at metaphyseal front, excessive osteoid deposition wide wrist space with cupping, decalcification of the metaphysis, and the cortex of long bones with subperiosteal erosion of the shafts. Vitamin D: from photosynthesis, metabolism, and action to clinical applications.